In the last decade a central role has been attributed to advanced glycation end products (AGE's) in the progression of accelerated atherosclerosis and progresion of chronic renal failure, especially in diabetic nephropathy. Deleterious effects of high AGE's concentration was observed mainly in diabetic hemodialyzed patients. D. M. type 2 is the most common cause of renal failure and renal replacement therapy in Poland and in the world. Diabetic complications are of huge medical and social interest. Therefore it is import ant to reveal all the mechanisms responsible for development of diabetic complications especially diabetic nephropatyhy. A significant role is also played by high cardiovascular mortality in hemodialysis patients, which is caused by atherosclerotic changes in vessels.