[Expression of estrogen receptor-related receptor alpha and estrogen receptor alpha in endometrial carcinoma and the primary investigation of their clinical significance].
Copyright policy )[Expression of estrogen receptor-related receptor alpha and estrogen receptor alpha in endometrial carcinoma and the primary investigation of their clinical significance].
To explore the roles of estrogen receptor-related receptor (ERR) alpha and estrogen receptor alpha in endometrial carcinoma and their clinical values.Thirty-five cases of endometrial carcinoma were examined by immunohistochemistry. Clinicopathologic features including FIGO stage, histological grade, myometrial invasion and nodal metastasis were reviewed.The expression rate of ERalpha in patients with FIGO stage I endometrial carcinoma was more than that in stage II-IV(P = 0.005). The expression rate of ERRalpha in endometrial carcinoma patients at FIGO stage I was lower than that at stages II-IV(P = 0.007). The percentage of patients at FIGO stageI or with G1-2 or myometrial invasion < 1/2 in ERalpha (+) and ERRalpha (-) groups was higher than that in ERalpha (-) and ERRalpha (+) groups(P = 0.000, P = 0.031 and P = 0.022).ERalpha may be a biomarker of good prognosis while ERRalpha may serve as a biomarker of poor prognosis in endometrial carcinoma. The combinative measure of ERalpha and ERRalpha may improve the prognostic value.
- Peking University China (People's Republic of)
Adult, ERRalpha Estrogen-Related Receptor, Estrogen Receptor alpha, Adenocarcinoma, Middle Aged, Prognosis, Endometrial Neoplasms, Receptors, Estrogen, Biomarkers, Tumor, Humans, Female, Neoplasm Invasiveness, Aged, Neoplasm Staging
Adult, ERRalpha Estrogen-Related Receptor, Estrogen Receptor alpha, Adenocarcinoma, Middle Aged, Prognosis, Endometrial Neoplasms, Receptors, Estrogen, Biomarkers, Tumor, Humans, Female, Neoplasm Invasiveness, Aged, Neoplasm Staging
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