[Incretins].

Insulin secretion is greater after peroral challenge than after intravenous glucose administration due to so-called incretin effect. The major incretins are glucagon-like peptide 1 and glucose-dependent-insulinotropic peptide. Physiology, pathophysiology and therapeutic implications of incretins in diabetes, neurodegenerative disorders and stress-induced hyperglycemia are concerned.

Keywords

Diabetes Mellitus, Type 2, Glucagon-Like Peptide 1, Hyperglycemia, Insulin Secretion, Animals, Humans, Insulin, Gastric Inhibitory Polypeptide

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