
To research the effect of glaucocalyxin A (GLA) on the level of Th1/Th2 type cytokines in mice.By using flow cytometer with CBA software to detect Th1/Th2 type cytokines.GLA had insighificant inhibitory effects on Th1 and Th2 cytokines (IL-2, IFN-gamma,TNF-alpha, IL-4 and IL-5) induced by ConA, in which more potential on cytokines from Th1 than those of from Th2 were displayed. However, GLA could produce inhibition on IL-2, IFN-gamma and TNF-alpha and acceleration on IL-4 and IL-5.Immunosuppressive effect of GLA is related to the influence the level of Th1/Th2 type cytokines.
Male, Mice, Inbred BALB C, Plants, Medicinal, Tumor Necrosis Factor-alpha, Th1 Cells, Interferon-gamma, Mice, Th2 Cells, Isodon, Animals, Cytokines, Interleukin-2, Female, Interleukin-4, Interleukin-5, Diterpenes, Kaurane, Drugs, Chinese Herbal
Male, Mice, Inbred BALB C, Plants, Medicinal, Tumor Necrosis Factor-alpha, Th1 Cells, Interferon-gamma, Mice, Th2 Cells, Isodon, Animals, Cytokines, Interleukin-2, Female, Interleukin-4, Interleukin-5, Diterpenes, Kaurane, Drugs, Chinese Herbal
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