Modulators and inhibitors of gamma- and beta-secretases.
Copyright policy )Modulators and inhibitors of gamma- and beta-secretases.
Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid precursor protein as a potential cause. The beta- and gamma-secretases are two executioners of amyloid precursor protein processing resulting in amyloid-beta. Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for gamma-secretase. Several peptidic and nonpeptidic leads were identified for both targets.
- TU Darmstadt Germany
Amyloid beta-Protein Precursor, Structure-Activity Relationship, Drug Design, Animals, Humans, Protease Inhibitors, Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor, Structure-Activity Relationship, Drug Design, Animals, Humans, Protease Inhibitors, Amyloid Precursor Protein Secretases
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).13 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!