[Significance of "anti HBC alone" serological profile in 284 patients suspicious of being infected with hepatitis B virus].
Copyright policy )[Significance of "anti HBC alone" serological profile in 284 patients suspicious of being infected with hepatitis B virus].
The "anti-HBc alone" serological profile is a frequent finding in hepatitis B virus infections, but little is known about its clinical significance. The aim of this study was to explore the 'anti-HBc alone' serological profile obtained by immunosorbent assay (ELISA) in 284 patients suspicious of being infected with hepatitis B virus. Sera were screened for following serological markers: HBs Ag, anti-HBc and anti-HBs antibodies using immunoradiometric assay (IRMA) and for HBV DNA using polymerase chain reaction. Among 284 studied sera with 'anti-HBc alone' serological profile, 124 were positives for anti-HBs antibodies by IRMA and corresponding to a recovered form of hepatitis B. Nineteen sera were negatives for anti-HBc antibodies, suggesting false positive results by ELISA. Two sera were found positives for HBs Ag by IRMA, which are related to authentic hepatitis B. HBV DNA was positive in 4 sera, suggesting occult hepatitis B. This study indicates that "anti-HBc alone" serological profile is most often correlates with recovered hepatitis B infection, but it can mask an occult hepatitis B.
Hepatitis B virus, Hepatitis B Surface Antigens, Radioimmunoassay, Enzyme-Linked Immunosorbent Assay, Hepatitis B, Hepatitis B Core Antigens, Polymerase Chain Reaction, DNA, Viral, Humans, False Positive Reactions, Immunoradiometric Assay, Hepatitis B Antibodies, Retrospective Studies
Hepatitis B virus, Hepatitis B Surface Antigens, Radioimmunoassay, Enzyme-Linked Immunosorbent Assay, Hepatitis B, Hepatitis B Core Antigens, Polymerase Chain Reaction, DNA, Viral, Humans, False Positive Reactions, Immunoradiometric Assay, Hepatitis B Antibodies, Retrospective Studies
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