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The long QT syndrome.

Authors: G. Michael Vincent;

The long QT syndrome.

Abstract

The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the primary cardiac arrhythmias or cardiac ion channelopathies. The study of inherited LQTS has provided enormous insight into the molecular basis of cardiac electrophysiology and arrhythmogenesis in general. Drug induced LQTS is the most common cause of acquired LQTS, and is a pressing public health issue. Considerable attention has been focussed on this form of LQTS following the withdrawal from the USA market of a number of prescription medications, including terfenedine in 2000 and cisapride in 2001. This review will discuss both forms, but with more emphasis on inherited LQTS.

Related Organizations
Keywords

RC666-701, acquired, long QT syndrome, congenital, Diseases of the circulatory (Cardiovascular) system, genetics

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    12
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Average
Average
Average
gold