Ultrastructure of the digestive gland has been studied in G. truncatula, uninfected and infected with F. hepatica larvae. The digestive gland of G. truncatula consist of secretory-resorption cells and calcareous cells. On the 20 day post infection the damage to the secretory cells were small and did not inhibit their activity. On the 60 day post infection the gland structure was totally altered: reduced height of secretory cells, lack of Golgi apparatus, myelin-like degradation of mitochondria, reduction and desintegrating of rough endoplasmic reticulum. These damage of secretory and calcareous cell to bring about a total inhibition of their secretory activities.