Recurrent aphthous stomatitis is a difficult to treat and quite common chronic inflammatory disease of the oral mucosa. This study evaluates the fluid extract from Chamomilla recutita's safety and effectiveness in pain relief from aphthous stomatitis and other painful ulcers of the oral mucous membrane. The analgesic effect was considered excellent by 82% and good by 18% of the patients, as demonstrated with the Analogical Visual Scale for chronic and experimental pains after 5, 10, and 15 minutes. Tolerance was evaluated as excellent by 97% and good by 1% of the subjects. The fluid extract from Chamomilla recutita, due to its analgesic effect, may give these patients a better quality of life.