[Comparison of the diagnostic value of recombinant antigens and synthetic peptides that mimic the immunogenic epitopes of the envelop protein gp41 in the enzyme immunodetection of HIV-1 antibodies].

E N, Baranova; V F, Puzyrev; O E, Van'kova; V K, Pimenov; A N, Burkov; A P, Obriadina; T I, Ulanova

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Article . 2006

Data sources: Europe PubMed Central

[Comparison of the diagnostic value of recombinant antigens and synthetic peptides that mimic the immunogenic epitopes of the envelop protein gp41 in the enzyme immunodetection of HIV-1 antibodies].

descriptionPublicationkeyboard_double_arrow_right Article 03 Aug 2006 Russian Journal:Voprosy virusologii, volume 51 (issn: 0507-4088,

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Authors: E N, Baranova; V F, Puzyrev; O E, Van'kova; V K, Pimenov; A N, Burkov; A P, Obriadina; T I, Ulanova;

pmid: 16826757

[Comparison of the diagnostic value of recombinant antigens and synthetic peptides that mimic the immunogenic epitopes of the envelop protein gp41 in the enzyme immunodetection of HIV-1 antibodies].

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Abstract

The study was undertaken to comparatively examine the efficiency of HIV antibody detection by enzyme immunoassay using recombinant antigens and synthetic peptides containing the most immunodominant region of the human immunodeficiency virus envelop protein gp41-cytotoxic T-lymphocytic (CTL) epitope. The application of the synthetic peptides that mimic this region has been to be inadequately effective. The recombinant proteins that contain the CTL epitope may be successfully used for the diagnosis of HIV-1, by using enzyme immunoassay as they show a higher sensitivity in detecting antibodies than do the synthetic peptises.

Keywords

Immunodominant Epitopes, Epitopes, T-Lymphocyte, HIV Infections, HIV Antibodies, HIV Envelope Protein gp41, Recombinant Proteins, Immunoenzyme Techniques, Predictive Value of Tests, HIV-1, Humans, Peptides

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