[Expression of Nestin, CK19, insulin, glucagon and somatostatin in embryonic pancreas].
Copyright policy )[Expression of Nestin, CK19, insulin, glucagon and somatostatin in embryonic pancreas].
To investigate the expression of Nestin, CK19, insulin, glucagon and somatostatin in the development of embryonic pancreas.Sample collection was conducted in accordance to the principle of informed consent. Immunohistochemical SABC method and LAB-SA for double satining were used to study the expression of the molecules in human embryonic pancreas.(1) There are few nestin-positive cells in the stroma of the embryonic pancreas. CK19 is consistently expressed in the epithelial cells of pancreatic ducts. (2) From 7 weeks of gestation, pancreatic duct epithelial cells begin to differentiate into insulin, glucagon and somatostatin-positive cells.Nestin-positive pancrease stem cells are in the stroma of human embryonic pancrease. Pancreatic duct epithelial cells differentiate into islet cells secreting insulin at the early stage of embryonic development.
- Sichuan University China (People's Republic of)
Keratin-19, Gene Expression Regulation, Developmental, Cell Differentiation, Epithelial Cells, Nerve Tissue Proteins, Glucagon, Nestin, Intermediate Filament Proteins, Pregnancy, Animals, Humans, Insulin, Female, Somatostatin, Pancreas
Keratin-19, Gene Expression Regulation, Developmental, Cell Differentiation, Epithelial Cells, Nerve Tissue Proteins, Glucagon, Nestin, Intermediate Filament Proteins, Pregnancy, Animals, Humans, Insulin, Female, Somatostatin, Pancreas
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