[Functional state of the dopaminergic system of the brain on a background of different doses of amitriptiline].
Copyright policy [Functional state of the dopaminergic system of the brain on a background of different doses of amitriptiline].
The aim of the work is study of adsorbtion dynamics of amitriptiline on the surface of erythrocytes and to compare the obtained data with the character of pharmacokinetics and pharmacodynamics of amitriptiline in plasma. With the method of PLC the adsorb gas was been analyzed. The drag was administered to adult drugs and the blood sampled were collected following 10, 20, 60 min. and 4,0; 6,0 and 8,0 hours after the injection. In the supernatants from the erythrocytes and in the blood plasma the dopaminergic systems has been analyzed. Our data proved the ability of amitriptiline to adsorb on the surface of erythrocytes. Its concentration in the supernatant washed from the surface of erythrocytes and in the blood were not the same. It may be connected with the character and quantity of functional groups located on the surface of erythrocytes.
Dogs, Dose-Response Relationship, Drug, Amitriptyline, Animals, Brain, Antidepressive Agents, Tricyclic, Injections, Intramuscular
Dogs, Dose-Response Relationship, Drug, Amitriptyline, Animals, Brain, Antidepressive Agents, Tricyclic, Injections, Intramuscular
citations The total number of citations received by all articles of the researcher of interest.0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!