Poly-L-lactic acid: an overview.
Copyright policy )Poly-L-lactic acid: an overview.
In August 2004, the US Food and Drug Administration approved a poly-L-lactic acid (PLLA)-based injectable medical device for restoration and/or correction of the signs of facial fat loss (lipoatrophy) in people with human immunodeficiency virus. As a result, the properties of the PLLA microparticles have received considerable interest from the medical community. Polylactides have a long-standing history of safe use in medical applications, such as pins, plates, screws, intra-bone and soft-tissue implants, and as vectors for sustained release of bioactive compounds. The L-isomer of polylactic acid is a biodegradable, biocompatible, biologically inert, synthetic polymer. Putatively, PLLA microparticles initiate neocollagenesis as a result of a normal foreign-body reaction to their presence. The build-up of collagen over time creates volume at the site of injection, while the PLLA microparticles are metabolized to carbon dioxide and water and expelled through the respiratory system.
Clinical Trials as Topic, Polymers, United States Food and Drug Administration, HIV-Associated Lipodystrophy Syndrome, Polyesters, Biocompatible Materials, Cosmetic Techniques, Prostheses and Implants, In Vitro Techniques, Injections, Intralesional, Risk Assessment, United States, Disease Models, Animal, Treatment Outcome, Absorbable Implants, Animals, Humans, Lactic Acid, Drug Approval, Follow-Up Studies
Clinical Trials as Topic, Polymers, United States Food and Drug Administration, HIV-Associated Lipodystrophy Syndrome, Polyesters, Biocompatible Materials, Cosmetic Techniques, Prostheses and Implants, In Vitro Techniques, Injections, Intralesional, Risk Assessment, United States, Disease Models, Animal, Treatment Outcome, Absorbable Implants, Animals, Humans, Lactic Acid, Drug Approval, Follow-Up Studies
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