
Bone morphogenetic protein (BMP)-2 markedly enhanced osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand (RANKL). RANKL expressed by osteoblasts is a requirement for osteoclastogenesis, osteoblasts also play important roles in osteoclastogenesis through offering the critical microenvironment for the action of RANKL.
Membrane Glycoproteins, Osteoblasts, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Bone Morphogenetic Protein 2, Osteoclasts, Cell Differentiation, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Animals, Humans, Bone Resorption, Carrier Proteins
Membrane Glycoproteins, Osteoblasts, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Bone Morphogenetic Protein 2, Osteoclasts, Cell Differentiation, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Animals, Humans, Bone Resorption, Carrier Proteins
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