During a period of 31 years, from January 1958 through 1988, a total of 449 operations had been performed on the in-patients whose blood type was recorded. There were 111 osteogenic sarcoma, 28 synovioma, 75 metastatic bone tumor, 172 giant cell tumor of bone, 14 fibrosarcoma, 28 chondrosarcoma, 11 Ewing's sarcoma, 10 chondrosarcoma, and 10 chordoma. The distribution of ABO blood type in these patients was processed statistically and compared with that of 268,794 normal blood donors registered in Shanghai, 1988. The analysis showed that people with blood type A were prone to develop synovioma and metastatic bone tumor but not osteogenic sarcoma. The authors tried to explain the above observation on basis of ABH blood type-substances and tried to make predictions by changes in trace elements in the bone tumor. Further implications on genetics and immunology is attempted.