Chemotherapy of trypanosomiasis: the potentiation of antimonial compounds by difluoromethylornithine (DFMO).

F W, Jennings

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Article . 1991

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Chemotherapy of trypanosomiasis: the potentiation of antimonial compounds by difluoromethylornithine (DFMO).

descriptionPublicationkeyboard_double_arrow_right Article 22 Oct 1991 English Journal:Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), volume 42 (issn: 0177-2392,

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Authors: F W, Jennings;

pmid: 1654590

Chemotherapy of trypanosomiasis: the potentiation of antimonial compounds by difluoromethylornithine (DFMO).

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Abstract

The currently available anti-leishmanial antimonial drugs, together with other antimony compounds were individually tested, in combination with difluoromethylornithine (DFMO), against experimental murine trypanosomiasis with central nervous system involvement. Satisfactory cure rates could be achieved using a combination treatment of DFMO with most of these anti-leishmanial drugs, but in general, only when they were administered at least twice daily. Of the compounds tested, the most effective was antimony dimercaptosuccinate (Astiban).

Related Organizations

University of Glasgow
United Kingdom

Keywords

Antimony, Eflornithine, Meglumine Antimoniate, Trypanosoma brucei brucei, Drug Synergism, Trypanocidal Agents, Mice, Meglumine, Trypanosomiasis, African, Antimony Sodium Gluconate, Organometallic Compounds, Animals, Drug Therapy, Combination, Female, Succimer, Tartrates

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