NF‐κB activation in melanoma
Copyright policy )NF‐κB activation in melanoma
SummaryMetastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor‐kappa B (NF‐κB) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF‐κB, (ii) mechanisms by which activated NF‐κB switch from pro‐apoptotic to anti‐apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF‐κB in metastatic melanoma.
- Vanderbilt University United States
- United States Department of Veterans Affairs United States
Skin Neoplasms, Transcription, Genetic, NF-kappa B, Up-Regulation, Gene Expression Regulation, Neoplastic, Autocrine Communication, Animals, Humans, Neoplasm Metastasis, Melanoma
Skin Neoplasms, Transcription, Genetic, NF-kappa B, Up-Regulation, Gene Expression Regulation, Neoplastic, Autocrine Communication, Animals, Humans, Neoplasm Metastasis, Melanoma
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).157 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!