Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia.
Copyright policy )Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia.
The polycythemia rubra vera 1 gene (PRV-1), a member of the urokinase-type plasminogen activator receptor superfamily, is overexpressed in granulocytes isolated from the peripheral blood of patients with polycythemia vera (PV) and essential thrombocythemia (ET). PRV-1 overexpression is the first reliable molecular marker of these myeloproliferative disorders, and its detection allows us to discriminate PV and ET from secondary erythrocytosis and thrombocytosis. PRV-1 overexpression can be investigated by several techniques, including Northern analysis, reverse-transcription (RT)-polymerase chain reaction (PCR), and real-time PCR. Among these, RT-PCR is the most rapid, reliable, and feasible method for the detection of PRV-1 overexpression in highly purified peripheral blood granulocytes.
Isoantigens, Membrane Glycoproteins, Reverse Transcriptase Polymerase Chain Reaction, Diagnosis, Differential; GPI-Linked Proteins; Granulocytes; Humans; Isoantigens; Membrane Glycoproteins; Polycythemia Vera; RNA; RNA, Messenger; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Thrombocythemia, Essential; Gene Expression Regulation, Receptors, Cell Surface, GPI-Linked Proteins, Diagnosis, Differential, Gene Expression Regulation, Humans, RNA, RNA, Messenger, Polycythemia Vera, Granulocytes, Thrombocythemia, Essential
Isoantigens, Membrane Glycoproteins, Reverse Transcriptase Polymerase Chain Reaction, Diagnosis, Differential; GPI-Linked Proteins; Granulocytes; Humans; Isoantigens; Membrane Glycoproteins; Polycythemia Vera; RNA; RNA, Messenger; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Thrombocythemia, Essential; Gene Expression Regulation, Receptors, Cell Surface, GPI-Linked Proteins, Diagnosis, Differential, Gene Expression Regulation, Humans, RNA, RNA, Messenger, Polycythemia Vera, Granulocytes, Thrombocythemia, Essential
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!