[Preliminary study on the alpha-glucosidase inhibitor from Glycyrrhiza uralensis Fisch].
Copyright policy )[Preliminary study on the alpha-glucosidase inhibitor from Glycyrrhiza uralensis Fisch].
To extract and isolate alpha-glucosidase inhibitor from Glycyrrhiza uralensis Fisch.The aqueous extract of Glycyrrhiza uralensis Fisch. was extracted by petroleum, ethyl acetate and n-butanol. In addition, the inhibitory activity against alpha-glucosidase of every fraction was determined and the inhibitory kinetics of ethyl acetate fraction was investigated.The inhibitory activities of four fractions were 68.93%, 83.2%, 32.17% and 10.79% respectively. Compared with the aqueous extract (69.77%), the inhibitory activity of ethyl acetate fraction was higher. Ethyl acetate fraction was shown to be a fast-binding, dose-dependent and competitive model with a Ki value of 34 microg/ml.It is hoped to obtain good alpha-glucosidase inhibitors by separating ethyl acetate fraction of aqueous extract of Glycyrrhiza uralensis Fisch further.
- Lanzhou University China (People's Republic of)
Plants, Medicinal, Dose-Response Relationship, Drug, Water, Glycoside Hydrolase Inhibitors, Glycyrrhiza uralensis, Spectrophotometry, Ultraviolet, alpha-Glucosidases, Acetates, Plant Roots, Rhizome, Drugs, Chinese Herbal
Plants, Medicinal, Dose-Response Relationship, Drug, Water, Glycoside Hydrolase Inhibitors, Glycyrrhiza uralensis, Spectrophotometry, Ultraviolet, alpha-Glucosidases, Acetates, Plant Roots, Rhizome, Drugs, Chinese Herbal
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