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A new RP-HPLC method for analysis of meloxicam in tablets.

Authors: M Saeed, Arayne; Najma, Sultana; Farhan Ahmed, Siddiqui;

A new RP-HPLC method for analysis of meloxicam in tablets.

Abstract

A simple and rapid high-performance liquid chromatographic (HPLC) method for the determination and quantification of meloxicam has been developed. The chromatographic system consisted of a Shimadzu LC-10 AT VP pump, SPD-10 AV VP UV/ visible detector, and a CBM-102 Bus Module integrator. Separation was achieved on the micro Bondapak 125 A C18 10 microm column at room temperature. The sample was introduced through an injector valve with a 10 microl sample loop. Methanol:water (70:30 v/v) was used as mobile phase, with flow rate 2 ml/minutes. pH was adjusted to 2.6 with phosphoric acid. U.V detection was performed at 230 nm. The results obtained showed a good agreement with the declared content. Recovery values of meloxicam in tablets (in Melfax 15 mg tablets) were from 99.27 % to 100.06 %. Piroxicam was used as an internal standard. The proposed method is rapid, accurate and selective; it may be used for the quantitative analysis of meloxicam from raw materials, in bulk drugs and other dosage formulations.

Related Organizations
Keywords

Thiazoles, Time Factors, Anti-Inflammatory Agents, Non-Steroidal, Thiazines, Reproducibility of Results, Meloxicam, Sensitivity and Specificity, Chromatography, High Pressure Liquid, Tablets

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
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