[Bone remodeling and mineral homeostasis].
Copyright policy )[Bone remodeling and mineral homeostasis].
The discovery of receptor activator of nuclear factor-kappaB ligand (RANKL) elucidates the mechanism of osteoclast differentiation and function regulated by osteoblasts. Osteoprotegerin (OPG), a soluble decoy receptor of RANKL, inhibits both differentiation and function of osteoclasts. OPG-deficient (OPG-/-) mice exhibited severe osteoporosis caused by enhanced osteoclastic bone resorption. Deficiency of OPG in human has been shown to result in juvenile Paget's disease. Blood alkaline phosphatase activity of OPG-/- mice was about four times as high as that of wild-type mice. These results suggest that osteoclastic bone resorption coincidentally induces osteoblastic bone formation by an unknown factor (called coupling factor). Collagen sponge disks containing bone morphogenetic protein-2 (rhBMP-2) were implanted into the dorsal muscle pouches in OPG-/- mice and wild-type mice, and bone mineral density (BMD) of the collagen sponge disks was determined every week for 3 weeks. No significant difference in BMD of the disc was observed between OPG-/- mice and wild-type mice. These results suggest that bone formation is accurately coupled with bone resorption at local sites in OPG-/- mice.
Membrane Glycoproteins, Osteoblasts, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Osteoprotegerin, Osteoclasts, Receptors, Cytoplasmic and Nuclear, Cell Differentiation, Receptors, Tumor Necrosis Factor, Mice, Bone Density, Bone Morphogenetic Proteins, Animals, Homeostasis, Bone Remodeling, Carrier Proteins, Glycoproteins
Membrane Glycoproteins, Osteoblasts, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Osteoprotegerin, Osteoclasts, Receptors, Cytoplasmic and Nuclear, Cell Differentiation, Receptors, Tumor Necrosis Factor, Mice, Bone Density, Bone Morphogenetic Proteins, Animals, Homeostasis, Bone Remodeling, Carrier Proteins, Glycoproteins
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!