Synthesis of some oxazolinones and imidazolinones and their antimicrobial screening

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2005 Croatia English Publisher:Croatian Pharmaceutical SocietyJournal:Acta Pharmaceutica, volume 55 (issn: 1330-0075, eissn: 1846-9558,

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Authors: DE, BIPLAB; GUPTA, JAYANTA KUMAR; SARAVANAN, VENKATAPURAM SAMPATH;

pmid: 16375839

Synthesis of some oxazolinones and imidazolinones and their antimicrobial screening

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Abstract

A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phenyl-4-acetylidene/benzylidene-imidazolin-5(4H)-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff's bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5(4H)-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imidazolin-5(4H)-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.

Sintetizirano je nekoliko novih derivata imidazolinona 1-aminoetil/fenil-2-metil/fenil-4-acetiliden/benziliden-imidazolin-5(4H)-ona iz odgovarajućeg acetiliden/benziliden oksazolinona. Reakcijom imidazolinona i benzaldehida pripravljene su Schiffove baze. Skoro svi spojevi posjeduju umjereno antimikrobno djelovanje na B. subtilis ATCC 6633 i K. pneumoniae ATCC 25063. Spojevi 10 1-aminofenil-2-fenil-4-acetiliden-imidazolin-5(4H)-on i 12 1-aminofenil-2-fenil-4-benziliden-imidazolin-5(4H)-on su čak aktivniji od amfotericina B na gljivicu C. albicans ATCC 29738.

Country

Croatia

Related Organizations

Jadavpur University
India

Keywords

antimicrobial activity, Molecular Structure, oksazolinoni, Schiff's bases, imidazolin-5(4H)-oni, Microbial Sensitivity Tests, oxazolinones, imidazolin-5(4H)-ones, antimikrobno djelovanje, Structure-Activity Relationship, Anti-Infective Agents, Schiffove baze, Imidazolines, Oxazoles

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