Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.
Copyright policy )Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin.
Nuclear targeting of beta-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes beta-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of beta-catenin. We speculate that cells may use multiple export mechanisms to inhibit beta-catenin signaling in different ways.
- NORTHWESTERN UNIVERSITY United States
- Northwestern University United States
- Northwestern University United States
- Northeastern University United States
- Northwestern University United States
Cell Nucleus, Nucleocytoplasmic Transport Proteins, Embryo, Nonmammalian, Active Transport, Cell Nucleus, Reviews, Nuclear Proteins, Receptors, Cytoplasmic and Nuclear, Exportin 1 Protein, Karyopherins, Wnt Proteins, Xenopus laevis, Drosophila melanogaster, Animals, Phosphorylation, beta Catenin, Signal Transduction
Cell Nucleus, Nucleocytoplasmic Transport Proteins, Embryo, Nonmammalian, Active Transport, Cell Nucleus, Reviews, Nuclear Proteins, Receptors, Cytoplasmic and Nuclear, Exportin 1 Protein, Karyopherins, Wnt Proteins, Xenopus laevis, Drosophila melanogaster, Animals, Phosphorylation, beta Catenin, Signal Transduction
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