Nephrogenic fibrosing dermopathy (NFD) is a scleromyxoedema-like disease favoring the extremities and trunk. Histologically there is a cellular fibrosis throughout the entire dermis. NFD is associated with renal insufficiency and dialysis, although the pathogenesis has not been elucidated. A 71-year-old woman developed classical symptoms of NFD on both legs within a few weeks after initiation of hemodialysis and concomitant antibiotic treatment followed by presumed drug eruption.