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[Dilated cardiomyopathy and lipid-lowering drug muscle toxicity revealing late-onset Becker's disease].

Authors: M A, Vandenhende; F, Bonnet; L, Sailler; S, Bouillot; P, Morlat; J, Beylot;

[Dilated cardiomyopathy and lipid-lowering drug muscle toxicity revealing late-onset Becker's disease].

Abstract

The Becker's muscular dystrophy is a genetic myopathy due to mutations of the dystrophin gene, located in the Xp21 region, with a clinical expression usually occurring in young adults.We report an atypical case of late onset Becker's muscular dystrophy diagnosed at the age of 57. The patient suffered from mild skeletal muscle involvement revealed by the use of statins and fibrates, associated with severe dilating cardiomyopathy. The DNA analysis showed a deletion of the exons 11-13 in the Xp21 gene.The diagnostic of Becker's muscular dystrophy must be considered in all patients with persistently elevated CPK and/or primitive dilated cardiomyopathy, whatever the age of the patient.

Keywords

Cardiomyopathy, Dilated, Male, Muscular Dystrophy, Duchenne, Humans, Age of Onset, Muscle, Skeletal, Gene Deletion, Aged, Hypolipidemic Agents

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Average
Average
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