The effect of Dilazep on F10 cells in vitro.

Experiments on F10 cell growth, colony ability, cell adhesion and ultramorphology at SEM have been performed. The effect of Dilazep (DIL) has been compared with that of well known modulating agents such as Flunarizine (FLU) and Verapamil (VER) on cells cultured in high Ca++ medium (HCM) and in low calcium medium (LCM). While in HCM there is no difference among the three drugs, FLU and VER had a stronger effect on cell growth inhibition in LCM. Cell adhesion to the growth substratum, evaluated by the technique of spontaneous detachment in culture medium, is reduced in DIL treated cells in comparison to the controls.

Country

Italy

Related Organizations

University of Padua
Italy
University of Udine
Italy
Alma Mater Studiorum University of Bologna
Italy

Keywords

Dilazep, Melanoma, Experimental, Animals; Calcium; Cell Adhesion; Cell Division; Cell Line; Dilazep; Flunarizine; Kinetics; Melanoma, Experimental; Mice; Tumor Cells, Cultured; Verapamil, Cell Line, Kinetics, Mice, Verapamil, Cell Adhesion, Tumor Cells, Cultured, Animals, Calcium antagonists; Dilazep; F10 cell line; Oncology; Cancer Research, Calcium, Cell Division, Flunarizine

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	5
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average