DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis.
Copyright policy )DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis.
The Disease Activity Score using 28 joint counts (DAS28) has been developed in a cohort of patients with rheumatoid arthritis in which only conventional anti-rheumatic treatments were used. It has extensively been validated to monitor disease activity in daily clinical practice as well as in clinical trials. The study of Vander Cruyssen and colleagues showed that the DAS28 correlated best with the decisions of rheumatologists to increase the infliximab dose because of insufficient response. This result once more confirms the validity of the DAS28 to monitor disease activity in patients with rheumatoid arthritis and to titrate treatment with biologicals.
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- Radboud University Nijmegen Netherlands
- Radboud University Nijmegen Medical Centre Netherlands
UMCN 4.2: Chronic inflammation and autoimmunity, Dose-Response Relationship, Drug, Antibodies, Monoclonal, Reproducibility of Results, N4i 1: Pathogenesis and modulation of inflammation, Severity of Illness Index, Infliximab, Autoimmune Diseases, Arthritis, Rheumatoid, Cohort Studies, N4i 4: Auto-immunity, transplantation and immunotherapy, Treatment Outcome, Evaluation Studies as Topic, Antirheumatic Agents, Commentary, Humans, NCEBP 2: Evaluation of complex medical interventions, Drug Monitoring
UMCN 4.2: Chronic inflammation and autoimmunity, Dose-Response Relationship, Drug, Antibodies, Monoclonal, Reproducibility of Results, N4i 1: Pathogenesis and modulation of inflammation, Severity of Illness Index, Infliximab, Autoimmune Diseases, Arthritis, Rheumatoid, Cohort Studies, N4i 4: Auto-immunity, transplantation and immunotherapy, Treatment Outcome, Evaluation Studies as Topic, Antirheumatic Agents, Commentary, Humans, NCEBP 2: Evaluation of complex medical interventions, Drug Monitoring
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