[The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum].
Copyright policy )[The solubilization effect of 2-hydroxypropyl-beta-cyclodextrin on paeonolum].
To study the solubilization effect of 2-hydroxypropyl-beta-cyclodextrin(HPCD) on paeonolum at various pH value.Phase-solubility method was adopted to study the solubilization effect at 25 degrees C and UV spectrohotometer was used to determine paeonolum content.The apparent solubility of paeonolum was significantly enhanced by increased HPCD concentration. The apparent stability constant of paeonolum compounds was calculated up to 1 425 in which pH was 3 and HPCD concentration was 133.33 mmol x L(-1). The solubility of paeonolum came up to 10 mg x mL(-1).HPCD is an ideal solubilizer for paeonolum.
- China Medical University China (People's Republic of)
Excipients, Plants, Medicinal, Drug Stability, Solubility, beta-Cyclodextrins, Acetophenones, Hydrogen-Ion Concentration, Paeonia, 2-Hydroxypropyl-beta-cyclodextrin
Excipients, Plants, Medicinal, Drug Stability, Solubility, beta-Cyclodextrins, Acetophenones, Hydrogen-Ion Concentration, Paeonia, 2-Hydroxypropyl-beta-cyclodextrin
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