[OPG, anti-rANKL antibody].
Copyright policy )[OPG, anti-rANKL antibody].
Identification of RANKL/ODF (receptor activator of NF-kappaB ligand/osteoclast differentiation factor), RANK(receptor activator of NF-kappaB) and OPG/OCIF(osteoprotegerin/ osteoclastogenesis inhibitory factor) revealed the mechanisms regulating osteoclast differentiation and function. RANKL-RANK signaling is essential for the physiological osteoclast development and plays a major role in the pathological bone destruction. OPG and anti-RANKL antibody act as a specific inhibitor of RANKL and are useful and applicable to osteoporosis and rheumatoid arthritis.
- University of Tokyo Japan
Membrane Glycoproteins, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Osteoprotegerin, Receptors, Cytoplasmic and Nuclear, In Vitro Techniques, Antibodies, Receptors, Tumor Necrosis Factor, Arthritis, Rheumatoid, Mice, Animals, Humans, Carrier Proteins, Glycoproteins
Membrane Glycoproteins, Receptor Activator of Nuclear Factor-kappa B, RANK Ligand, Osteoprotegerin, Receptors, Cytoplasmic and Nuclear, In Vitro Techniques, Antibodies, Receptors, Tumor Necrosis Factor, Arthritis, Rheumatoid, Mice, Animals, Humans, Carrier Proteins, Glycoproteins
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