Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.

FAENZA, IRENE; BILLI, ANNA MARIA; FOLLO, MATILDE YUNG; FIUME, ROBERTA; MARTELLI, ALBERTO MARIA; COCCO, LUCIO ILDEBRANDO; MANZOLI, LUCIA

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Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Article . 2005

Data sources: Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Anticancer Research

Article . 2005

Data sources: Europe PubMed Central

Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2005 Italy English Journal:Anticancer research, volume 25 (issn: 0250-7005,

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Authors: FAENZA, IRENE; BILLI, ANNA MARIA; FOLLO, MATILDE YUNG; FIUME, ROBERTA; MARTELLI, ALBERTO MARIA; COCCO, LUCIO ILDEBRANDO; MANZOLI, LUCIA;

pmid: 16158942

handle: 11585/6169

Nuclear phospholipase C signaling through type 1 IGF receptor and its involvement in cell growth and differentiation.

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Abstract

The existence of a nuclear polyphosphoinositol metabolism, independent from that at the plasma cell membrane, is now widely recognized. Specific changes in the nuclear phosphatidylinositol (PtdIns) metabolism have been implicated in cell growth, differentiation and neoplastic transformation. Here, the main features of nuclear inositol lipid signaling through type I IGF receptor, is reviewed with particular attention to the role of inositide-specific phospholipase C (PI-PLC) beta1 in cell proliferation and differentiation, due to the peculiar localization of this molecule in the nuclear compartment.

Country

Italy

Related Organizations

Alma Mater Studiorum University of Bologna
Italy

Keywords

Cell Nucleus, Phospholipase C beta, Cell Differentiation, Cell Growth Processes, Phosphatidylinositols, Receptor, IGF Type 1, Enzyme Activation, Isoenzymes, Myoblasts, Type C Phospholipases, Animals, Insulin-Like Growth Factor I, Signal Transduction

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