Challenges of immune responses in gene replacement therapy.

Hildegund C J, Ertl

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Article . 2005

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Challenges of immune responses in gene replacement therapy.

descriptionPublicationkeyboard_double_arrow_right Article 12 Dec 2005 English Journal:IDrugs : the investigational drugs journal, volume 8 (issn: 1369-7056,

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Authors: Hildegund C J, Ertl;

pmid: 16118696

Challenges of immune responses in gene replacement therapy.

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Abstract

Permanent gene replacement therapy using viral carriers such as adenovirus or adenovirus-associated virus vectors has failed thus far in human patients, in part due to immune responses to antigens of the viral carrier, a problem that has remained underappreciated and thus largely unaddressed.

Related Organizations

The Wistar Institute
United States

Keywords

T-Lymphocytes, Genetic Vectors, Humans, Dendritic Cells, Genetic Therapy, Antigens, Viral, Immunologic Memory, Immunity, Innate

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