[Castleman's disease].
Copyright policy )[Castleman's disease].
To describe original experience in management of Castleman's disease (CD) and review literature data.Twelve cases of HIV-free CD in patients aged 18-51 years (mean age 36 years) are reported.CD was plasmocell, mixed and hyalinovascular in 6, 2 and 4 patients, respectively. Histological and immunophenotypical characteristics of CD are detailed. Three patients with plasmocell CD died of severe autoimmune anemia. All the patients with hyalinovascular KD variant were treated surgically (enlarged lymph nodes were removed) and achieved remission.The diagnosis of plasmocell CD is made after exclusion of infections, collagenoses, autoimmune diseases and lymphomas. Therapy of plasmocell variant of CD has not been developed yet.
Adult, Male, Adolescent, Castleman Disease, Plasma Cells, Middle Aged, Diagnosis, Differential, Humans, Lymph Node Excision, Female, Anemia, Hemolytic, Autoimmune, Lymph Nodes, Follow-Up Studies
Adult, Male, Adolescent, Castleman Disease, Plasma Cells, Middle Aged, Diagnosis, Differential, Humans, Lymph Node Excision, Female, Anemia, Hemolytic, Autoimmune, Lymph Nodes, Follow-Up Studies
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