[corrected] To investigate the differences and similarities between non-erosive reflux disease (NERD) and reflux disease (RE).This study covered 30 patients who were grouped by endoscopy into the cases of NERD (n=17) or RE (n=13). The two groups' symptom, mentality, and damage to life quality were compared. Biopsy was performed at 3 cm above LES in oesophagus. The patients were placed under ambulatory 24-h oesophageal pH and Bilitec2000 monitoring. And their responses to the same anti-reflux treatment were evaluated.(1) The proportion of female (58.82%) in NERD group was much higher than that (15.38%) in RE group (P0.05). But in respect to mentality, the NERD group had significantly higher anxiety and depression scores than did the RE group (P0.05). (4) The NERD group had less abnormal reflux, compared with the RE group (P<0.05). (5) The NERD group gave less response to treatment, compared to the RE group (P<0.05).NERD may be a kind of reflux disease different from RE.