[Effects of Icariin on ovariectomized osteoporotic rats].
Copyright policy )[Effects of Icariin on ovariectomized osteoporotic rats].
To observe the effects of Icariin on ovariectomized osteoporotic rats.Female Wistar rats were ovariectomized and administered different dosage of Icariin and 17beta-estradiol for eight weeks. Bone mineral density (BMD), indexes of biomechanics and bone metabolism-associated biochemical markers were measured.Icariin increased the BMD, maximum load and flexural rigidity in the osteoporotic rats. The activities of serum tartrate-resistant acid phosphatase (TRACP) and bone alkaline phosphatase (BALP) were decreased in the Icraiin-fed ovariectomized rats.Icariin 225mg/kg per day could increase the BMD and improve indexes of bone biomechanics in ovariectomized osteoporotic rats. It was effective in preventing bone loss induced by ovariectomy.
- Northeast Agricultural University China (People's Republic of)
Flavonoids, Dose-Response Relationship, Drug, Tartrate-Resistant Acid Phosphatase, Ovariectomy, Acid Phosphatase, Alkaline Phosphatase, Biomechanical Phenomena, Rats, Isoenzymes, Bone Density, Animals, Osteoporosis, Female, Rats, Wistar, Drugs, Chinese Herbal
Flavonoids, Dose-Response Relationship, Drug, Tartrate-Resistant Acid Phosphatase, Ovariectomy, Acid Phosphatase, Alkaline Phosphatase, Biomechanical Phenomena, Rats, Isoenzymes, Bone Density, Animals, Osteoporosis, Female, Rats, Wistar, Drugs, Chinese Herbal
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