[Biotransformation of mexidol in inbred BALB/C and C57BL/6 mice].

S B, Seredenin; O Iu, Kravtsova; A K, Sarieva; V P, Zherdev; G B, Kolyvanova; T A, Voronina

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2005

Data sources: Europe PubMed Central

[Biotransformation of mexidol in inbred BALB/C and C57BL/6 mice].

descriptionPublicationkeyboard_double_arrow_right Article 02 Aug 2005 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 68 (issn: 0869-2092,

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Authors: S B, Seredenin; O Iu, Kravtsova; A K, Sarieva; V P, Zherdev; G B, Kolyvanova; T A, Voronina;

pmid: 15934366

[Biotransformation of mexidol in inbred BALB/C and C57BL/6 mice].

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Abstract

The pharmacokinetics and biotransformation of mexidol was studied in BALB/C and C57BL/6 mice. The blood plasma contains dealkylated metabolites, and the urine contains glucuronoconjugated derivatives of the drug. The process of glucuronoconjugation more intensively proceeds in C57BL/6 mice than in BALB/C mice.

Keywords

Male, Mice, Mice, Inbred BALB C, Psychotropic Drugs, Species Specificity, Picolines, Animals, Tissue Distribution, Biotransformation

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