NF-kappa B comes home.

NF-kappa B was discovered because of its binding to the Ig kappa locus intronic enhancer, but deletion of its binding site does not appear to affect V-to-J kappa rearrangement. New work by Verkoczy et al. in this issue of Immunity suggests that NF-kappa B regulates Ig kappa rearrangement after all, by activating RAG expression during receptor editing.

Keywords

Homeodomain Proteins, Immunoglobulin kappa-Chains, Enhancer Elements, Genetic, NF-kappa B, Animals

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