Epidemiological problems connected with hepatitis A in twentieth century and in the first years of twenty-first were mentioned with special attention of self-limiting of cases in the periods of very high, high, medium, low and very low endemicity. Decreasing of percentage of immunised persons was observed especially among children and young persons. It may be a cause in future of increasing of numbers of cases of hepatitis A even epidemics. Therefore vaccination against hepatitis A some people in risk groups is now recommended. Especially are included persons with some professions (health workers, persons employed in food and meals industry, travellers to the region of high or medium endemicity etc), persons living in territory of poor sanitary conditions, children, adolescents and young adults as well as persons with some chronic diseases, drug addicts, homosexuals.