It is important for prevention of vascular complications in diabetics to control blood glucose, blood pressure, and dyslipidemia, and to stop smoking. Recently, it has been reported that the HMG-CoA reductase inhibitor has angiogenetic effects independent of lipid lowering effect. Moreover, gene therapy using VEGF and HGF has shown dramatic effects for peripheral arterial disease. Endothelial progenitor cells injection is also expected for treatment of ischemic heart disease.