To develop a system for three-dimensional (3D) non-contact measurement of breast using computer-aided projection fringe measurement (CAPFM).A system of 3D non-contact breast measurement was developed based on CAPFM and used for measurement of a plastic model mimicking human breast.The CAPFM system was capable of non-contact 3D measurement with rapid data collection (within 0.5 s) and measurement (no longer than -3 min). This system was highly automatic, and with software-controlled measurement, the sensitivity was as high as 0.6 mm (for linear measurement) and 1 ml (for volume measurement), to well meet the clinical requirements. The measurement results could be stored and expressed in numerical values or represented in vivid 2D figures and 3D images, which facilitated subsequent studies.The 3D non-contact breast measurement system on the basis of CAPFM can be helpful for medical assessment of the breast.