[Development of purified HFRS bivalent vaccine].

Shi-long, Yang; Guan-mu, Dong; Juan, Li; Qi, An; Xiao-dong, Sun; Xiao-hui, Sun; Ping, Li

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Article . 2009

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[Development of purified HFRS bivalent vaccine].

descriptionPublicationkeyboard_double_arrow_right Article 24 Apr 2009Journal:Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, volume 21 (issn: 1007-8738,

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Authors: Shi-long, Yang; Guan-mu, Dong; Juan, Li; Qi, An; Xiao-dong, Sun; Xiao-hui, Sun; Ping, Li;

pmid: 15766416

[Development of purified HFRS bivalent vaccine].

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Abstract

To develop the purified HFRS bivalent vaccine.LR1 (type I) and R22 (type II) of HFRS virus were cultured respectively in Vero cells. The viral suspensions were harvested, inactivated with beta-propiolactone, concentrated by ultra-filtration, purified by zone centrifugation, and desucrosed by column chromatography. The qualified vaccine bulks of type I and type II were mixed equally and absorbed with AI(OH)3 for preparation of 3 lots vaccines.The 3 lots vaccines all passed examination carried out by ourselves and reexamination performed by National Institute for the Control of Pharmaceutical and Biological Products . One of 3 lots has been used in clinical trial.It is practical to develop the purified HFRS bivalent vaccine by Vero cell culture.

Keywords

Quality Control, Clinical Trials as Topic, Chlorocebus aethiops, Animals, Humans, Immunization, Viral Vaccines, Vero Cells, Hantaan virus

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