Central venous catheter-related Wangiella dermatitidis infection has been increasingly reported in the recent literature. We report a case of central venous catheter (Port-A-Cath)-related fungemia caused by W. dermatitidis in a 58-year-old woman with lung cancer. Two W. dermatitidis isolates were recovered from 2 blood samples drawn from a peripheral vein and the Port-A-Cath 4 months after its placement. The minimum inhibitory concentrations of 2 isolates to fluconazole and amphotericin B using the standard broth microdilution method were 48 microg/mL and 0.19 microg/mL, respectively. The Port-A-Cath was removed and the fungemia responded to amphotericin B treatment. W. dermatitidis should be categorized as a pathogen that can cause central venous catheter-associated fungemia, particularly in immunocompromised patients.