[Preparations for serodiagnosis of diseases due to causative agents of ixode tick-borne Borreliosis (Lyme disease). Communication 2. Comparative study of recombinant enzyme immunoassay test-systems (rELISA) for serological diagnosis of ixode tick-borne Borreliosis].

I N, Manzeniuk; M S, Vorob'eva; N M, Nikitiuk; E A, Arumova; L P, Anan'eva; S G, Baranova; T G, Viatkina; A V, Masiago; A A, Kozarenko; Iu A, Andreĭchuk

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Антибиотики и Химиот...arrow_drop_down

Антибиотики и Химиотерапия

Article . 2005

Data sources: Europe PubMed Central

[Preparations for serodiagnosis of diseases due to causative agents of ixode tick-borne Borreliosis (Lyme disease). Communication 2. Comparative study of recombinant enzyme immunoassay test-systems (rELISA) for serological diagnosis of ixode tick-borne Borreliosis].

descriptionPublicationkeyboard_double_arrow_right Article 29 Jun 2005 Russian Journal:Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], volume 49 (issn: 0235-2990,

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Authors: I N, Manzeniuk; M S, Vorob'eva; N M, Nikitiuk; E A, Arumova; L P, Anan'eva; S G, Baranova; T G, Viatkina; +3 Authors

pmid: 15727142

[Preparations for serodiagnosis of diseases due to causative agents of ixode tick-borne Borreliosis (Lyme disease). Communication 2. Comparative study of recombinant enzyme immunoassay test-systems (rELISA) for serological diagnosis of ixode tick-borne Borreliosis].

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Abstract

One foreign and two Russian recombinant enzyme immunoassay test-systems were comparatively investigated under conditions of an encoded experiment. Sensitivity in the experiment with the Russian test-systems Borreliosis-ELISA-IgG and Lyme Best was 63.8 and 68.8% respectively. As for the test-system Borrelia IgG Recombinant, it was 47.5%. All the test-systems were highly specific (94.4 to 99.5%). The test-systems Lyme Best and Borrelia IgG Recombinant revealed partial cross reactions with sera from patients with systemic lupus erythematosus and leptospirosis.

Keywords

Antigens, Bacterial, Lyme Disease, Enzyme-Linked Immunosorbent Assay, Cross Reactions, Antibodies, Bacterial, Sensitivity and Specificity, Recombinant Proteins, Borrelia burgdorferi Group, Immunoglobulin G, Humans, Serologic Tests, Reagent Kits, Diagnostic

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