[Recombinant analysis of classical swine fever virus].

To study the possible recombinant relationship among differently derived classical swine fever virus, the coding regions of 21 isolates were analyzed to detect recombination and breakpoints through gene trees comparison and quartet analyses. The results show nucleotide area corresponding to E0, E1 and E2 as a possible recombinant tract between ALD ( D49532) and GPE-(D49533) while NS5A-NS5B of the isolate 39 (AF407339) appears to be derived from a virulent Shimen strain (AF092448) sequence. This suggests that intertypic exchanges of genetic materials during mixed infections under natural or laboratorial conditions can lead classical swine fever virus to adapt to the changes of host environment.

Related Organizations

Wuhan University
China (People's Republic of)

Keywords

Evolution, Molecular, Recombination, Genetic, Likelihood Functions, Open Reading Frames, Classical Swine Fever Virus, Computational Biology, Sequence Alignment, Phylogeny

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