[Investigation of the effects of mexidol in escapable and inescapable emotional stress in inbred BALB/C and C57BL/6 mice].
Copyright policy )[Investigation of the effects of mexidol in escapable and inescapable emotional stress in inbred BALB/C and C57BL/6 mice].
The effect of mexidol administered in a dose of 100 mg/kg (i.p.) was studied in BALB/C and C57BL/6 mice on various emotional stress models including open field test, elevated plus-maze test, and passive avoidance conditioned reflex. Upon a single administration, the drug produces a selective anxiolytic action on BALB/C mice (experimental animals with a "passive" phenotype of the emotional stress reaction), while not inducing any sedative (tranquilizer) effect in C57BL/6 mice (belonging to the phenotype with "active" emotional stress reaction).
Male, Mice, Mice, Inbred BALB C, Behavior, Animal, Species Specificity, Picolines, Animals, Maze Learning, Stress, Psychological
Male, Mice, Mice, Inbred BALB C, Behavior, Animal, Species Specificity, Picolines, Animals, Maze Learning, Stress, Psychological
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