Cytotoxic activity against a series of human tumour cell lines of some diorganotin(iv) 1,2-ethylenediamine N,N'-diacetates, N-(2-hydroxyethyl)- and N-(carbamoylmethyl)-iminodiacetates, and ortho-aminobenzoates.
Copyright policy )Cytotoxic activity against a series of human tumour cell lines of some diorganotin(iv) 1,2-ethylenediamine N,N'-diacetates, N-(2-hydroxyethyl)- and N-(carbamoylmethyl)-iminodiacetates, and ortho-aminobenzoates.
The di-n-butyltin(IV) derivatives of N-(2-hydroxyethyl)- and N-(carbamoylmethyl)- iminodiacetic acid, compounds 1 and 2, the di-n-butyltin-, di-n-octyltin and dimethyltin-(IV) derivatives of 1,2-ethylene diamine N,N'-diacetic acid, compounds 3, 4 and 5, and di-n-butyltin bis-o-aminobenzoate, compound 6, were tested in vitro at the National Cancer Institute, Bethesda, Maryland, USA, for cytotoxic activity against a series of human tumor cell lines. Compounds 1 and 2 score globally satisfactorily since four of the five relevant selectivity or sensitivity parameters [DGI50, DTGI or DLC50 greater than 50, DH and MGDH greater than 75)] are statistically significant; compounds 4 and 6 score satisfactorily for only three of these parameters and compound 3, for only two. Compound 5, the dimethyltin derivative, is inactive.
info:eu-repo/semantics/published
Journal Article
- Vrije Universiteit Brussel Belgium
- Université Libre de Bruxelles Belgium
Cultured, Organotin Compounds, Tumor Cells, Cultured, Humans, Aminobenzoates, Antineoplastic Agents, Chimie organométallique, Salicylates, Tumor Cells
Cultured, Organotin Compounds, Tumor Cells, Cultured, Humans, Aminobenzoates, Antineoplastic Agents, Chimie organométallique, Salicylates, Tumor Cells
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