[The relationship of DNA methylation and histone methylation].
Copyright policy [The relationship of DNA methylation and histone methylation].
In and out of the eukaryotic genomes, there exist many covalent modifications, of which are the methylation of DNA and histones, and they are both involved in genes silencing, in which the methylation of DNA and H3K9 are synergistic, but the methylation of H3K4 is antagonistic to them. The recent studies showed that these two methylations are correlated, that is, DNA methylation is dependent on the methylation of H3K9. However, the relationship of these two methylations is more complicated in mammals than in lower eukaryotons and plants.
- Nanjing Agricultural University China (People's Republic of)
Histones, Animals, Humans, Gene Silencing, Histone-Lysine N-Methyltransferase, DNA Methylation, Methylation
Histones, Animals, Humans, Gene Silencing, Histone-Lysine N-Methyltransferase, DNA Methylation, Methylation
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