
It has been shown that intact-PTH assay measures not only full-length biologically active PTH with 84 amino acids, but also some PTH fragments such as (7-84) PTH. Whole-PTH assay is a new method believed to react only with (1-84) PTH. Because circulatory concentrations of various fragments of PTH are very high especially in patients with secondary hyperparathyroidism associated with renal failure, evaluation of PTH levels by whole-PTH assay seems to be useful for accurate assessment of parathyroid function in these patients.
Parathyroid Hormone, Humans, Hyperparathyroidism, Secondary, Immunoradiometric Assay, Renal Insufficiency, Biomarkers
Parathyroid Hormone, Humans, Hyperparathyroidism, Secondary, Immunoradiometric Assay, Renal Insufficiency, Biomarkers
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