[Treatment of lumbar intervertebral disc displacement with chondroitinase ABC--experimental basis for clinical application].
Copyright policy )[Treatment of lumbar intervertebral disc displacement with chondroitinase ABC--experimental basis for clinical application].
After single intradiscal injection of C-ABC in rabbit inter-vertebral discs, water content in the matrix of nucleus pulposus diminished clearly. After similar injection of C-ABC in sheep discs, disc inner pressure was diminished. After single intradiscal injection of C-ABC in dog inter-vertebral discs suffering disc herniation, the syndromes coming from the herniation diminished or disappeared. Based on these observations C-ABC is expected to be a chemonucleolytic agent and a human clinical trial is now in progress.
- Central Research Laboratories (United Kingdom) United Kingdom
- Seikagaku Corporation (Japan) Japan
Dogs, Lumbar Vertebrae, Sheep, Intervertebral Disc Chemolysis, Animals, Humans, Rabbits, Chondroitin ABC Lyase, Injections, Intralesional, Intervertebral Disc Displacement
Dogs, Lumbar Vertebrae, Sheep, Intervertebral Disc Chemolysis, Animals, Humans, Rabbits, Chondroitin ABC Lyase, Injections, Intralesional, Intervertebral Disc Displacement
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