[Heparin inhibits metastatization of experimental melanoma].
Copyright policy )[Heparin inhibits metastatization of experimental melanoma].
Heparin treatment, at human equivalent doses, modulates coagulation parameters in mice similarly to the human situation. Heparins were tested in various melanoma metastasis models for their antimetastatic activity. Heparins were active against melanoma metastasis without influencing the primary tumor. Tumor cell-induced platelet aggregation was not the primary target of heparins, since melanoma cells were not active in this respect. Our results support the notion that heparins have antimetastatic activity.
Mice, Cell Movement, Heparin, Cell Adhesion, Melanoma, Experimental, Animals, Humans, Antineoplastic Agents, Cell Proliferation
Mice, Cell Movement, Heparin, Cell Adhesion, Melanoma, Experimental, Animals, Humans, Antineoplastic Agents, Cell Proliferation
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