To evaluate the results and significance of Coat's disease with argon laser photocoagulation and cryotherapy.22 patients (23 eyes) were treated by argon laser (German Opton Meditek 40 E, 0.2w power, 100-500 um spot, 0.1-0.2 second exposure and grade II reaction) and or scleral cryotherapy (-60 to approximately -80 degrees C, 5 second duration per time, repeating treatment if necessary until pale edema was seen in retina).18 eyes in all (78.2%) had good results with visual acuity improvement and the lesion of fundus had been seen decreased in varient degrees. The follow-up ranged from 1 to 3 years.Photocoagulation and scleral cryotherapy are effective for those patients with Coat's disease. It is very important to treat them promptly so as to prevent the damage of visual function progressively.